[HTML][HTML] Tristetraprolin expression by keratinocytes controls local and systemic inflammation
M Andrianne, A Assabban, C La, D Mogilenko… - JCI insight, 2017 - ncbi.nlm.nih.gov
Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates the mRNA stability of several
important cytokines. Due to the critical role of this RNA-binding protein in the control of …
important cytokines. Due to the critical role of this RNA-binding protein in the control of …
Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice
C Kress, C Gautier-Courteille, HB Osborne… - … and Cellular Biology, 2007 - Am Soc Microbiol
Abstract CUG-BP1/CELF1 is a multifunctional RNA-binding protein involved in the
regulation of alternative splicing and translation. To elucidate its role in mammalian …
regulation of alternative splicing and translation. To elucidate its role in mammalian …
[HTML][HTML] The role of tristetraprolin in cancer and inflammation
S Sanduja, FF Blanco, LE Young, V Kaza… - Frontiers in bioscience …, 2012 - ncbi.nlm.nih.gov
Messenger RNA decay is a critical mechanism to control the expression of many
inflammation-and cancer-associated genes. These transcripts are targeted for rapid …
inflammation-and cancer-associated genes. These transcripts are targeted for rapid …
[HTML][HTML] Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and-independent mechanisms
BA Johnson, JR Stehn, MB Yaffe… - Journal of Biological …, 2002 - ASBMB
The immediate early gene tristetraprolin (TTP) is induced transiently in many cell types by
numerous extracellular stimuli. TTP encodes a zinc finger protein that can bind and …
numerous extracellular stimuli. TTP encodes a zinc finger protein that can bind and …
The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription
K Chowdhury, M Goulding, C Walther, K Imai… - Mechanisms of …, 1992 - Elsevier
We describe the complete nucleotide sequence of a full length cDNA clone encoding a new
mouse zinc finger protein gene, Zfp-38 and localize it on chromosome 5 by the interspecific …
mouse zinc finger protein gene, Zfp-38 and localize it on chromosome 5 by the interspecific …
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
WS Lai, E Carballo, JR Strum… - … and cellular biology, 1999 - Am Soc Microbiol
Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH zinc finger proteins,
develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α) …
develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α) …
A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in …
P Griseri, C Bourcier, C Hieblot… - Human molecular …, 2011 - academic.oup.com
Post-transcriptional regulation plays a central role in cell differentiation and proliferation.
Among the regulatory factors involved in this mechanism, Tristetraprolin (ZFP36 or TTP) is …
Among the regulatory factors involved in this mechanism, Tristetraprolin (ZFP36 or TTP) is …
[HTML][HTML] Tristetraprolin specifically regulates the expression and alternative splicing of immune response genes in HeLa cells
Y Tu, X Wu, F Yu, J Dang, J Wang, Y Wei, Z Cai… - BMC immunology, 2019 - Springer
Background Tristetraprolin (TTP) is an RNA binding protein that plays a critical role in
regulating proinflammatory immune responses by destabilizing target mRNAs via binding to …
regulating proinflammatory immune responses by destabilizing target mRNAs via binding to …
Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis
H Cao, LJ Deterding, JD Venable… - Biochemical …, 2006 - portlandpress.com
Tristetraprolin (TTP) is a zinc-finger protein that binds to AREs (AU-rich elements) within
certain mRNAs and causes destabilization of those mRNAs. Mice deficient in TTP develop a …
certain mRNAs and causes destabilization of those mRNAs. Mice deficient in TTP develop a …
Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline
S Maezawa, K Hasegawa, M Yukawa… - Proceedings of the …, 2018 - National Acad Sciences
Repressive H3K27me3 and active H3K4me2/3 together form bivalent chromatin domains,
molecular hallmarks of developmental potential. In the male germline, these domains are …
molecular hallmarks of developmental potential. In the male germline, these domains are …