Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin
Tristetraprolin (TTP) is an RNA-binding protein that controls the inflammatory response by
limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally …
limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally …
Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28
Tristetraprolin (TTP) is a AU-rich element (ARE) binding protein and exhibits suppressive
effects on cell growth through down-regulation of ARE-containing oncogenes. The let-7 …
effects on cell growth through down-regulation of ARE-containing oncogenes. The let-7 …
Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein
The human ZC3H14 gene encodes an evolutionarily conserved Cys3His zinc finger protein
that binds specifically to polyadenosine RNA and is thus postulated to modulate post …
that binds specifically to polyadenosine RNA and is thus postulated to modulate post …
Identification of ZFR, an ancient and highly conserved murine chromosome-associated zinc finger protein
MJ Meagher, JM Schumacher, K Lee, RW Holdcraft… - Gene, 1999 - Elsevier
In a screen for RNA binding proteins expressed during murine spermatogenesis, we cloned
a novel, ancient zinc finger protein possessing a region common to a small class of RNA …
a novel, ancient zinc finger protein possessing a region common to a small class of RNA …
RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich …
BY Brewer, J Malicka, PJ Blackshear… - Journal of Biological …, 2004 - ASBMB
Tristetraprolin (TTP) binds AU-rich elements (AREs) encoded within selected labile mRNAs
and targets these transcripts for rapid cytoplasmic decay. RNA binding by TTP is mediated …
and targets these transcripts for rapid cytoplasmic decay. RNA binding by TTP is mediated …
An ancient family of RNA-binding proteins: still important!
ML Wells, L Perera, PJ Blackshear - Trends in biochemical sciences, 2017 - cell.com
RNA-binding proteins are important modulators of mRNA stability, a crucial process that
determines the ultimate cellular levels of mRNAs and their encoded proteins. The …
determines the ultimate cellular levels of mRNAs and their encoded proteins. The …
Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition
Rapid cellular zinc influx regulates early mammalian development during the oocyte-to-egg
transition through modulation of the meiotic cell cycle. Despite the physiological necessity of …
transition through modulation of the meiotic cell cycle. Despite the physiological necessity of …
Post-transcriptional regulation of immune responses and inflammatory diseases by RNA-binding ZFP36 family proteins
S Makita, H Takatori, H Nakajima - Frontiers in immunology, 2021 - frontiersin.org
Post-transcriptional regulation is involved in the regulation of many inflammatory genes. Zinc
finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger …
finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger …
Roles of tristetraprolin in tumorigenesis
Genetic loss or mutations in tumor suppressor genes promote tumorigenesis. The
prospective tumor suppressor tristetraprolin (TTP) has been shown to negatively regulate …
prospective tumor suppressor tristetraprolin (TTP) has been shown to negatively regulate …
The mouse DXZ4 homolog retains Ctcf binding and proximity to Pls3 despite substantial organizational differences compared to the primate macrosatellite
AH Horakova, JM Calabrese, CR McLaughlin… - Genome biology, 2012 - Springer
Background The X-linked macrosatellite DXZ4 is a large homogenous tandem repeat that in
females adopts an alternative chromatin organization on the primate X chromosome in …
females adopts an alternative chromatin organization on the primate X chromosome in …