In many animals, establishment of the germ line depends on segregation of a specialized
cytoplasm, or 'germ plasm', to a small number of germline precursor cells during early …

The immediate early protein tristetraprolin (TTP) is required to prevent inappropriate
production of the cytokine TNF-α, and is a member of a zinc finger protein family that is …

Background ZFP36, also known as tristetraprolin or TTP, and ELAVL1, also known as HuR,
are two disease-relevant RNA-binding proteins (RBPs) that both interact with AU-rich …

TTP is an anti-inflammatory protein that acts by binding to AREs in its target mRNAs, such as
Tnf mRNA, and promoting their deadenylation and decay. TNF released from inflammatory …

Cancer and senescence are both complex transformative processes that dramatically alter
many features of cell physiology and their interactions with surrounding tissues. Developing …

Expression of the immediate early protein tristetraprolin (TTP) is induced by numerous
stimuli, including tumor necrosis factor-alpha (TNFα). Evidence indicates that TTP limits …

Tristetraprolin (TTP) is an RNA-binding protein required for the rapid degradation of mRNAs
containing AU-rich elements. Targets regulated by TTP include the mRNAs encoding tumor …

The main characteristic of cancers, including breast cancer, is the ability of cancer cells to
proliferate uncontrollably. However, the underlying mechanisms of cancer cell proliferation …

STUDY QUESTION Can any new genetic factors responsible for early embryonic arrest in
infertile patients be identified, together with the mechanism of pathogenic variants …

Tristetraprolin (TTP) is a hyperphosphorylated protein that destabilizes mRNA by binding to
an AU-rich element (ARE). Mice deficient in TTP develop a severe inflammatory syndrome …