Polycomb group (PcG) proteins are essential for maintenance of lineage fidelity by
coordinating developmental gene expression programs. Polycomb group ring finger 6 …

Meiotic resumption‐coupled degradation of maternal transcripts occurs during oocyte
maturation in the absence of mRNA transcription. The CCR 4–NOT complex has been …

Tristetraprolin (TTP) is a member of the CCCH tandem zinc-finger class of proteins. It can
bind to and destabilize mRNAs encoding tumor necrosis factor-α (TNF-α) and granulocyte …

Transforming growth factor-β (TGF-β) is a pleiotropic cytokine that plays a critical role in
modulating immune response and inflammation. We employed the Affymetrix cDNA …

Initiation of timely and sufficient zygotic genome activation (ZGA) is crucial for the beginning
of life, yet our knowledge of transcription factors (TFs) contributing to ZGA remains limited …

Tristetraprolin (TTP) is the only trans-acting factor shown to be capable of regulating AU-rich
element-dependent mRNA turnover at the level of the intact animal; however, the …

During spermatogenesis, meiosis is accompanied by a robust alteration in gene expression
and chromatin status. However, it remains elusive how the meiotic transcriptional program is …

Background Recurrent preimplantation embryo developmental arrest (RPEA) is the most
common cause of assisted reproductive technology treatment failure associated with …

Mammalian fertilisation begins when sperm interacts with the egg zona pellucida (ZP),
whose ZP1 subunit is important for fertility by covalently cross-linking ZP filaments into a …

Background Smchd1 is an epigenetic modifier essential for X chromosome inactivation:
female embryos lacking Smchd1 fail during midgestational development. Male mice are less …