AIM: To investigate CpG methylation and single nucleotide polymorphism (SNP) of a specific
promoter region of hMLH1 in primary gastric carcinoma. METHODS: Primary gastric …

To determine whether methylation of the hMLH1 promoter is related to increasing age and
gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric …

Background: Human mutL homolog 1 (hMLH1) is located on chromosome 3q21-23. As a
classic tumor suppressor gene, many researchers have studied the association between …

Hypermethylation of CpG islands in the promoter region is associated with the silencing of a
variety of tumor suppressor genes. DNA repair genes human Mut L homologue 1 (hMLH1) …

AIM: Hypermethylation of the promoter of the hMLH1 gene, which plays an important role in
mismatch repair during DNA replication, occurs in more than 30% of human gastric cancer …

To determine the etiological factors of human colorectal cancer (CRC) we assessed the
frequency and prognostic significance of hMLH1 and hMSH2 genes in conjunction with …

A significant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as
microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with …

Introduction Gastric cancer (GC) is one of the leading causes of cancer-related death in Iran.
Genome stability is one of the main genetic issues in cancer biology which is governed via …

AIM: To explore germline hypermethylation of the tumor suppressor genes MLH1, CDH1
and P16 INK4a in suspected cases of hereditary gastric cancer (GC). METHODS: A group of …

Purpose Epigenetic silencing of the DNA mismatch repair genes has been poorly described
in colorectal carcinomas showing the classic adenoma–carcinoma pathway of …