Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 Å resolution: implications for superantigen recognition by MHC class II molecules and T …
AC Papageorgiou, HS Tranter, KR Acharya - Journal of molecular biology, 1998 - Elsevier
Staphylococcal enterotoxin B is a member of a family of toxins known as superantigens that
activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T …
activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T …
The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules
M Håkansson, K Petersson, H Nilsson… - Journal of molecular …, 2000 - Elsevier
The X-ray structure of the superantigen staphylococcal enterotoxin H (SEH) has been
determined at 1.69 Å resolution. In this paper we present two structures of zinc-free SEH …
determined at 1.69 Å resolution. In this paper we present two structures of zinc-free SEH …
Crystal structure of the superantigen staphylococcal enterotoxin type A.
EM Schad, I Zaitseva, VN Zaitsev, M Dohlsten… - The EMBO …, 1995 - embopress.org
Staphylococcal enterotoxins are prototype superantigens characterized by their ability to
bind to major histocompatibility complex (MHC) class II molecules and subsequently activate …
bind to major histocompatibility complex (MHC) class II molecules and subsequently activate …
Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site
AC Papageorgiou, KR Acharya, R Shapiro… - Structure, 1995 - cell.com
Background: Staphylococcus aureus enterotoxin C2 (SEC2) belongs to a family of proteins,
termed 'superantigens', that form complexes with class II MHC molecules enabling them to …
termed 'superantigens', that form complexes with class II MHC molecules enabling them to …
Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule
MM Fernández, R Guan, CP Swaminathan… - Journal of Biological …, 2006 - ASBMB
Superantigens are bacterial or viral proteins that elicit massive T cell activation through
simultaneous binding to major histocompatibility complex (MHC) class II and T cell …
simultaneous binding to major histocompatibility complex (MHC) class II and T cell …
The Co-crystal structure of staphylococcal enterotoxin type A with Zn2+ at 2.7 Å resolution: implications for major histocompatibility complex class II binding
M Sundström, D Hallén, A Svensson, E Schad… - Journal of Biological …, 1996 - ASBMB
Superantigens form complexes with major histocompatibility complex (MHC) class II
molecules and T-cell receptors resulting in extremely strong immunostimulatory properties …
molecules and T-cell receptors resulting in extremely strong immunostimulatory properties …
Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell …
Staphylococcus aureus produces a virulence factor, protein A (SpA), that contains five
homologous Ig-binding domains. The interactions of SpA with the Fab region of membrane …
homologous Ig-binding domains. The interactions of SpA with the Fab region of membrane …
A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarity
EM Schad, AC Papageorgiou, LA Svensson… - Journal of molecular …, 1997 - Elsevier
Staphylococcal enterotoxins and toxic shock syndrome toxin-1 are known as superantigens
due to their ability to activate a large number of T-cells by crosslinking the major …
due to their ability to activate a large number of T-cells by crosslinking the major …
Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules
Bacterial superantigens are small proteins that have a very potent stimulatory effect on T
lymphocytes through their ability to bind to both MHC class II molecules and T-cell receptors …
lymphocytes through their ability to bind to both MHC class II molecules and T-cell receptors …
Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1
SUPERANTIGENS stimulate T cells bearing particular T-cell receptor Vβ sequences1, 2, so
they are extremely potent polyclonal T-cell mitogens. T-cell activation is preceded by binding …
they are extremely potent polyclonal T-cell mitogens. T-cell activation is preceded by binding …