Treatment-resistant depression (TRD) is a growing area of discussion among researchers
and medical professionals. Varying resistance levels among patients with TRD pose …

Depression affects millions of people worldwide, with no regard to socioeconomic status or
ethnic background. Treatment resistance, defined as the lack of response to first-line, widely …

Treatment-resistant depression (TRD) is a major public health problem in terms of its
prevalence and in terms of individual suffering and cost to society. Best estimates indicate …

Background Patients with major depression respond to antidepressant treatment, but 10%–
30% of them do not improve or show a partial response coupled with functional impairment …

Introduction: Treatment-resistant depression (TRD) is a complex, multifactorial, and
biologically heterogeneous disorder with debilitating outcomes. Understanding individual …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

Treatment-resistant depression (TRD) refers to depression that fails to remit after at least two
to four medication and psychotherapy treatment strategies. TRD carries significant personal …

BACKGROUND: Treatment-resistant depression (TRD) presents a unique challenge in
managed care, requiring review of both the clinical and economic components of care …

In this narrative review, we intended to summarize the evidence of pharmacological and
somatic treatment choices for treatment-resistant depression (TRD). There are several types …

When an antidepressant fails to help a depressed patient, clinicians are faced with the
daunting task of choosing the next treatment. Several pharmacologic and nonpharmacologic …