OBJECTIVE—Ruboxistaurin selectively inhibits protein kinase C-β and ameliorates kidney
disease in animal models of diabetes. The purpose of this study was to evaluate the effects …

Diabetic nephropathy (DN) has emerged as the major causative pathology in patients
entering end‐stage renal disease (ESRD) worldwide and it is responsible for 30–40% of all …

Protein kinase C (PKC), a family of 12 distinct serine-threonine kinases, is an important
intracellular signaling pathway involved in various cellular functions, such as proliferation …

Activation of protein kinase C (PKC) isoforms has been implicated in the pathogenesis of
diabetic nephropathy. We showed earlier that PKC-α is activated in the kidneys of …

In patients with diabetes, the hyperglycaemia is known to promote high levels of
diacylglycerol which activates protein kinase C (PKC) in the vascular tissues and leads to …

Background: Nephropathy is a major cause of morbidity and mortality in diabetic patients.
Current treatments include optimization of glycemic and blood pressure control, but more …

Rapidly increasing rates of diabetes throughout the developed world represent an emerging
epidemic with profound consequences. This epidemic is likely to drive previously …

High-glucose-induced activation of mesangial cell protein kinase C (PKC) contributes
significantly to the pathogenesis of diabetic nephropathy. Excess glucose metabolism …

Hyperglycemic control in diabetes is key to preventing the development and progression of
vascular complications such as retinopathy, nephropathy and neuropathy. Increased …