Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive
deficits and apathy, with a heritability estimated at 73–90%(ref.). Inheritance patterns are …

Reduced fecundity, associated with severe mental disorders, places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Schizophrenia is an etiologically heterogeneous psychiatric disease, which exists in familial
and nonfamilial (sporadic) forms. Here, we examine the possibility that rare de novo copy …

Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

In a small fraction of patients with schizophrenia or autism, alleles of copy-number variants
(CNVs) in their genomes are probably the strongest factors contributing to the pathogenesis …

Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to
genetic alterations, but identifying the genes responsible has proved challenging …

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …

Schizophrenia is a common disease with a complex aetiology, probably involving multiple
and heterogeneous genetic factors. Here, by analysing the exome sequences of 2,536 …

Schizophrenia is a severe psychiatric disorder that profoundly affects cognitive, behavioral
and emotional processes. The wide spectrum of symptoms and clinical variability in …

We investigated the involvement of rare (< 1%) copy number variants (CNVs) in 471 cases
of schizophrenia and 2792 controls that had been genotyped using the Affymetrix …