Approximately 30% of epilepsy cases are refractory to current pharmacological treatments.
Thus, novel therapeutic approaches that prevent or reverse the molecular and cellular …

The 5-hydroxytryptamine 7 (5-HT7) receptor is the most recently classified member of the
serotonin receptor family. The localization of 5-HT7 receptors and the biological activity of its …

Background: Epilepsy is a syndrome of brain dysfunction caused by spontaneous, abnormal
discharge. Many anti-epileptic drugs have developed in past decades. 5-HT is an important …

Recent studies have documented that reduced M-current promotes epileptogenesis and
attenuates synaptic remodeling. Neurite growth is closely related to the level of 5-HT6 …

The localization of serotonin-7 (5-HT7) receptors and the biological activity of ligands have
suggested that 5-HT7 receptors might be involved in pain, migraine, epilepsy, anxiety …

Aims Substantial evidence indicates that 5‐HT 2C receptors are involved in the control of
neuronal network excitability and in seizure pathophysiology. Here, we have addressed the …

There is some evidence that epileptic seizures could be induced or increased by 5-
hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the …

Accepted: 25 December 2023© Center for Excellence in Brain Science and Intelligence
Technology, Chinese Academy of Sciences 2024 potential of mTORC2 as a target for broad …

The mTOR signaling pathway has emerged as a possible therapeutic target for epilepsy.
Clinical trials have shown that mTOR inhibitors such as everolimus reduce seizures in …

Of the many serotonin receptors, the type 3 receptors (5-HT3R) are the only ionotropic ones,
playing a key role in fast synaptic transmission and cognitive and emotional brain function …