Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation
L Sivertsson, I Edebert, MP Palmertz… - Molecular …, 2013 - ASPET
We have previously shown that confluent growth of the human hepatoma cell line Huh7
substantially induces the CYP3A4 mRNA, protein, and activity levels. Here, the mechanisms …
substantially induces the CYP3A4 mRNA, protein, and activity levels. Here, the mechanisms …
Estrogen enhances induction of cytochrome P-4501A1 by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in liver of female Long-Evans rats.
S Sarkar, NR Jana, J Yonemoto… - International …, 2000 - spandidos-publications.com
Abstract A human carcinogen, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) induces liver
tumors in female rats. In this study, we examined the effects of estrogen on an …
tumors in female rats. In this study, we examined the effects of estrogen on an …
20-HETE-producing enzymes are up-regulated in human cancers
A Alexanian, B Miller, RJ Roman… - Cancer genomics & …, 2012 - cgp.iiarjournals.org
Background: 20-Hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid
(AA) produced by the CYP4A and CYP4F enzyme families has been reported to induce …
(AA) produced by the CYP4A and CYP4F enzyme families has been reported to induce …
Aberrant estrogen receptor alpha expression correlates with hepatocellular carcinoma metastasis and its mechanisms.
ML Sheng, GL Xu, CH Zhang, WD Jia… - Hepato …, 2014 - europepmc.org
Results The expression of ERalpha and p-ERalpha was lower in HCC with PVTT than those
without PVTT. Meanwhile, the expression pattern of above parameters was also similar in …
without PVTT. Meanwhile, the expression pattern of above parameters was also similar in …
[HTML][HTML] Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis
AIM To investigate gender-specific liver estrogen receptor (ER) expression in normal
subjects and patients with hepatitis C virus (HCV)-related cirrhosis and hepatocellular …
subjects and patients with hepatitis C virus (HCV)-related cirrhosis and hepatocellular …
Co-expression of drug metabolizing cytochrome P450 enzymes and estrogen receptor alpha (ESR1) in human liver: racial differences and the regulatory role of ESR1
JM Collins, D Wang - Drug metabolism and personalized therapy, 2021 - degruyter.com
Objectives The function and expression of cytochrome P450 (CYP) drug metabolizing
enzymes is highly variable, greatly affecting drug exposure, and therapeutic outcomes. The …
enzymes is highly variable, greatly affecting drug exposure, and therapeutic outcomes. The …
[HTML][HTML] 17β-Estradiol promotes apoptosis of HepG2 cells caused by oxidative stress by increasing Foxo3a phosphorylation
Y Guo, X Cai, H Lu, Q Li, Y Zheng, Z Lin… - Frontiers in …, 2021 - frontiersin.org
Liver cancer is associated with high mortality, particularly in patients infected with the
hepatitis B virus. Treatment methods remain very limited. Here, we explored the effects of …
hepatitis B virus. Treatment methods remain very limited. Here, we explored the effects of …
[HTML][HTML] Dietary erythrodiol modifies hepatic transcriptome in mice in a sex and dose-dependent way
R Abuobeid, L Herrera-Marcos, MA Navarro… - International Journal of …, 2020 - mdpi.com
Erythrodiol is a terpenic compound found in a large number of plants. To test the hypotheses
that its long-term administration may influence hepatic transcriptome and this could be …
that its long-term administration may influence hepatic transcriptome and this could be …
A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells
H Takemura, H Uchiyama, T Ohura… - The Journal of steroid …, 2010 - Elsevier
A 17β-estradiol (E2) is hydrolyzed to 2-hydroxy-E2 (2-OHE2) and 4-hydroxy-E2 (4-OHE2)
via cytochrome P450 (CYP) 1A1 and 1B1, respectively. In estrogen target tissues including …
via cytochrome P450 (CYP) 1A1 and 1B1, respectively. In estrogen target tissues including …
[HTML][HTML] Estrogen receptor-α suppresses liver carcinogenesis and establishes sex-specific gene expression
Simple Summary The hormone estrogen is well known for its role in promoting breast and
ovarian cancer. Estrogen has the opposite effect on the liver, which it protects from cancer …
ovarian cancer. Estrogen has the opposite effect on the liver, which it protects from cancer …