Results from clinical studies suggest that pregnancy alters hepatic drug metabolism in a
cytochrome P450 (P450) isoform-specific manner, and rising concentrations of female …

The ACI rat is extremely sensitive to estrogens as mammary carcinogens, whereas the
Sprague–Dawley strain is relatively resistant. Comparison of the disposition and effects of …

Cytochrome P4502C19 (CYP2C19) is an important drug-metabolizing enzyme involved in
the biotransformation of, for example, proton pump inhibitors and antidepressants. Several …

Abstract Cytochrome P450 2E1 (CYP2E1) is known as a heme-containing enzyme that
produces abundant free radicals, and its involvement in carcinogenesis has been suggested …

Estradiol induces kidney tumors in Syrian hamsters. The elevated conversion of estradiol to
4-hydroxylated metabolites in kidney compared to the predominant 2-hydroxylation in liver …

The role of estrogen in the expression and induction of hepatic Cyp2b and Cyp3a isoforms
was studied using mice [Ar (−/−) mice] lacking aromatase, a key enzyme for estrogen …

Induction of cytochrome P450 (CYP) 1A1 and CYP1B1 by environmental xenobiotic
chemicals or endogenous ligands through the activation of the aryl hydrocarbon receptor …

Cytochrome P450 epoxygenases (CYP450) have been recently shown to promote
malignant progression. Here we investigated the mRNA and protein expression and …

Hepatocyte tumor cell lines lack the expression or induction properties of major cytochrome
P450 (CYP) enzymes compared to primary human hepatocytes. The Ras/Raf/MEK/ERK …

Estradiol (E2) is the major endogenous estrogen, and its plasma concentration increases up
to 100-fold during pregnancy in humans. Accumulating evidence suggests that an elevated …