Rationale: Exacerbation of chronic obstructive pulmonary disease commonly causes
hospitalization. The change in lung mechanics during exacerbation and its relationship to …

Acute exacerbations of chronic obstructive disease (AECOPD) are characterised by
worsening dyspnoea that is variably prolonged. In this study, physiological changes during …

Expiratory airway collapse is a characteristic feature in patients with chronic obstructive
pulmonary disease (COPD). We hypothesized that this collapse might mask the effects of …

Chronic obstructive pulmonary disease (COPD) is defined by progressive, irreversible
airflow limitation and an inflammatory response of the lungs, usually to cigarette smoke …

Objective: To determine the direction and rate of change in the symptom of dyspnea in
patients with chronic obstructive pulmonary disease (COPD) whose lung function has …

The purpose of this study was to examine longitudinal changes in clinical parameters in
patients with chronic obstructive pulmonary disease (COPD). We postulated that progressive …

Although exacerbations of chronic obstructive pulmonary disease (COPD) are associated
with symptomatic and physiological deterioration, little is known of the time course and …

Bronchodilator drugs produce variable improvements in forced expiratory volume in 1 s
(FEV1), but larger changes in end-expiratory lung volume (EELV) in chronic obstructive …

We hypothesized that an altered effect of lung inflation on airway caliber may in part explain
the isolated volume response to bronchodilators, ie, an increase of forced vital capacity …

Background Guidelines recommend that symptoms as well as lung function should be
monitored for the management of patients with chronic obstructive pulmonary disease …