Introduction Oxidative stress activates multiple signaling transduction pathways, including
the phosphatidylinositol 3-kinase (PI3-K), in an injured intestine as occurs in necrotizing …

C6 rat glioma cells are one of the most aggressive carcinogenic tumors, due to its high
mortality rate in human beings and animals. The current treatment for this illness includes …

To defend against the potential damages induced by reactive oxygen species, proliferating
cells enter a transient cell cycle arrest. We treated mouse fibroblasts with H 2 O 2 and found …

Medulloblastoma (MB) is a common and highly aggressive pediatric brain tumor of a
heterogeneous nature. According to transcriptome-based profiling, four molecular …

As an efficient reactive oxygen species–scavenging enzyme, superoxide dismutase (SOD)
has been shown to inhibit tumor growth and interfere with motility and invasiveness of …

Modulation of cerebral cell metabolism for improving the outcome of hypoxia-ischemia and
reperfusion is a strategy yet to be explored. Because carbon monoxide (CO) is known to …

Cell growth arrest is an adaptation process for tumor survival in hypoxic environments. As
proliferation is a very complicated and dynamic process, hypoxic growth arrest is not …

Background Cycling hypoxia is a well-recognized phenomenon within animal and human
solid tumors. It contributes to the resistance to cytotoxic therapies through anti-apoptotic …

Low oxygen concentrations (hypoxia) occur in several physiological and pathological
cellular situations such as embryogenesis and stem cell modulation (in terms of …

Loss of caspase-8 expression–which has been demonstrated in a subset of
Medulloblastoma (MB)–might block important apoptotic signalling pathways and therefore …