Background Cycling hypoxia is a well-recognized phenomenon within animal and human
solid tumors. It contributes to the resistance to cytotoxic therapies through anti-apoptotic …

Abstract Background Cyclooxygenase-2 (COX-2), an inflammation-associated enzyme, has
been implicated in tumorigenesis and progression of glioblastoma (GBM). The poor survival …

It has been proposed that reactive oxygen species (ROS), mainly superoxide anion ($ O_2^-
$) and hydrogen peroxide ($ H_2O_2 $), may mediate oxidative stress. Production of …

Hypoxia-ischemia (HI) can result in permanent life-long injuries such as motor and cognitive
deficits. In response to cellular stressors such as hypoxia, tumor suppressor protein p53 is …

Oxygen (O2) is a substrate for energy production in the cell and is a rapid regulator of
cellular metabolism. Recent studies have also implicated O2 and its signal transduction …

Loss of caspase-8 expression–which has been demonstrated in a subset of
Medulloblastoma (MB)–might block important apoptotic signalling pathways and therefore …

Increased dopamine catabolism may be associated with oxidative stress and neuronal cell
death in Parkinson's disease. The present study was carried out to examine the effect of …

The effects and potential molecular mechanisms underlying carbon dioxide (CO 2)
pneumoperitoneum on gastric cancer cell apoptosis are not fully understood. In this study …

Oxygen concentration should be carefully regulated in all living tissues, beginning at the
early embryonic stages. Unbalances in oxygen regulation can lead to cell death and …

Peritoneal carcinomatosis of colorectal cancer is common and associated with poor
prognosis, which poses a serious challenge and satisfactory treatments are urgently …