Genetics and genomics of congenital heart disease

S Zaidi, M Brueckner - Circulation research, 2017 - Am Heart Assoc
Congenital heart disease is the most common birth defect, and because of major advances
in medical and surgical management, there are now more adults living with congenital heart …

Genetic basis of human congenital heart disease

SN Nees, WK Chung - Cold Spring Harbor perspectives …, 2020 - cshperspectives.cshlp.org
Congenital heart disease (CHD) is the most common major congenital anomaly with an
incidence of∼ 1% of live births and is a significant cause of birth defect–related mortality …

Genomic frontiers in congenital heart disease

SU Morton, D Quiat, JG Seidman… - Nature Reviews …, 2022 - nature.com
The application of next-generation sequencing to study congenital heart disease (CHD) is
increasingly providing new insights into the causes and mechanisms of this prevalent birth …

[HTML][HTML] Genetics of congenital heart disease: a narrative review of recent advances and clinical implications

J Yasuhara, V Garg - Translational Pediatrics, 2021 - ncbi.nlm.nih.gov
Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

Molecular genetics and complex inheritance of congenital heart disease

NS Diab, S Barish, W Dong, S Zhao, G Allington, X Yu… - Genes, 2021 - mdpi.com
Congenital heart disease (CHD) is the most common congenital malformation and the
leading cause of mortality therein. Genetic etiologies contribute to an estimated 90% of CHD …

Genetic insights into normal and abnormal heart development

M Nemer - Cardiovascular Pathology, 2008 - Elsevier
Congenital heart defects (CHDs) affect 1–2% of newborn children and are the leading cause
of death in infants under 1 year of age. CHDs represent the single largest class of birth …

The genetics of isolated congenital heart disease

SN Nees, WK Chung - … Journal of Medical Genetics Part C …, 2020 - Wiley Online Library
The genetic mechanisms underlying congenital heart disease (CHD) are complex and
remain incompletely understood. The majority of patients with CHD have an isolated heart …

Genetic contribution to congenital heart disease (CHD)

NA Shabana, SU Shahid, U Irfan - Pediatric cardiology, 2020 - Springer
Congenital heart defects (CHD) are the most common congenital problems in neonates. The
basis for CHD is multifactorial, involving genetic and environmental components. The …

Genetics of congenital heart disease

JJ Edwards, BD Gelb - Current opinion in cardiology, 2016 - journals.lww.com
Recent technological advances have rapidly expanded our understanding of CHD genetics,
and support the applicability to the clinical domain in both sporadic and inherited disease …

Advances in the understanding of the genetic determinants of congenital heart disease and their impact on clinical outcomes

MW Russell, WK Chung, JR Kaltman… - Journal of the American …, 2018 - Am Heart Assoc
Congenital heart defects (CHDs) are the most common type of birth defect occurring in% 1%
of live births1 and, if minor cardiac abnormalities such as bicuspid aortic valve are included …