Compounds that target D2-like dopamine receptors (DRs) are currently used as therapeutics
for several neuropsychiatric disorders including schizophrenia (antagonists) and …

The abuse of illicit psychostimulants such as cocaine and methamphetamine continues to
pose significant health and societal challenges. Despite considerable efforts to develop …

Cocaine is a psychostimulant and a drug widely abused by humans. Cocaine elicits its
effects primarily by blocking the activity of the dopamine (DA) transporter, leading to …

Gold and Blum's early work led to the classic concept of DA depletion in psychostimulant
abuse (ie cocaine) and DA and norepinephrine's (NE) role in alcohol/opiate withdrawal [11 …

Designer receptors exclusively activated by designer drugs (DREADDs) have proven to be
highly effective neuromodulatory tools for the investigation of neural circuits underlying …

Designer receptors exclusively activated by designer drugs (DREADD)-based
chemogenetic tools are extensively used to manipulate neuronal activity in a cell type …

In the absence of selective agonists and antagonists able to discriminate between individual
members of the D 1-like and D 2-like families of dopamine receptor subtypes, functional …

Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric disorder characterized by
inattention, aberrant impulsivity, and hyperactivity. Although the underlying pathophysiology …

Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a
therapeutic strategy for neurologic and psychiatric diseases due to the fundamental role of …

Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known.
The critical role of DA in addiction is supported by converging evidence that has been …