Summary The D1-and D2-dopamine receptors (D1R and D2R), which signal through G s
and G i, respectively, represent the principal stimulatory and inhibitory dopamine receptors …

We used inhibitory DREADDs (designer receptors exclusively activated by designer drugs)
to reversibly disrupt dorsolateral prefrontal cortex (dlPFC) function in male rhesus monkeys …

The neuromodulator dopamine (DA) is essential for regulating learning, motivation, and
movement. Despite its importance, however, the mechanisms by which DA influences the …

Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can
selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively …

Medication-assisted treatments are unavailable to patients with cocaine use disorders.
Efforts to develop potential pharmacotherapies have led to the identification of a promising …

The dopamine transporter (DAT) plays an important homeostatic role in the control of both
the extracellular and intraneuronal concentrations of dopamine, thereby providing effective …

The chemogenetic technology referred to as designer receptors exclusively activated by
designer drugs (DREADDs) offers reversible means to control neuronal activity for …

Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …

Novel dopamine (DA) receptor proteins of relatively low natural abundance and uncertain
physiology can be expressed selectively in genetically transfected cultured cells to facilitate …

Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release,
but their ability to detect a wide range of extracellular DA levels, especially tonic versus …