Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.

F Weiss, MT Lorang, FE Bloom, GF Koob - Journal of Pharmacology and …, 1993 - ASPET
Dopaminergic neurotransmission in the nucleus accumbens may be an important factor in
ethanol reinforcement and genetically determined ethanol preference. This hypothesis was …

The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat

S Rassnick, L Stinus, GF Koob - Brain research, 1993 - Elsevier
Rats readily learn to self-administer ethanol using a procedure where ethanol is introduced
in the presence of a sweetener. After gradual removal of the sweetener, sufficient quantities …

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

S Rassnick, L Pulvirenti, GF Koob - Psychopharmacology, 1992 - Springer
The purpose of this study was to assess the role of endogenous dopamine and glutamate
systems within the nucleus accumbens in modulating responses for oral ethanol …

Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens

HH Samson, CW Hodge, GA Tolliver, M Haraguchi - Brain research bulletin, 1993 - Elsevier
Rats initiated to self-administer 10% ethanol (v/v) in an operant situation using the sucrose-
substitution technique received bilateral n. accumbens or caudate nucleus microinjections of …

Alcohol self‐administration: further examination of the role of dopamine receptors in the nucleus accumbens

CW Hodge, HH Samson… - Alcoholism: Clinical and …, 1997 - Wiley Online Library
One of the functions of the mesolimbic dopamine (DA) system is to regulate the process of
reinforcement, a process that is thought to influence drug self‐administration. This study …

Microdialysis of dopamine in the nucleus accumbens of alcohol‐preferring (P) rats during anticipation and operant self‐administration of ethanol

RI Melendez, ZA Rodd‐Henricks… - Alcoholism: Clinical …, 2002 - Wiley Online Library
Background: The present study was designed to test directly whether a contextual stimulus
for access to ethanol would acquire the ability to enhance locomotor activity and dopamine …

Effect of operant self‐administration of 10% ethanol plus 10% sucrose on dopamine and ethanol concentrations in the nucleus accumbens

WM Doyon, SK Anders… - Journal of …, 2005 - Wiley Online Library
Although operant ethanol self‐administration can increase accumbal dopamine activity, the
relationship between dopamine and ethanol levels during consumption remains unclear …

Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent …

X Liu, F Weiss - Journal of Pharmacology and Experimental …, 2002 - ASPET
Mesocorticolimbic dopamine (DA) transmission has been implicated in the consummatory
and, more recently, the incentive-motivational aspect of ethanol's actions. The purpose of …

Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats

RJ Thielen, EA Engleman, ZA Rodd, JM Murphy… - … of Pharmacology and …, 2004 - ASPET
The alcohol deprivation effect is a temporary increase in the intake of, or preference for,
ethanol after a period of deprivation that may result from persistent changes in key limbic …

Dopamine activity in the nucleus accumbens during consummatory phases of oral ethanol self‐administration

WM Doyon, JL York, LM Diaz… - Alcoholism: Clinical …, 2003 - Wiley Online Library
Background: This present study was designed to clarify the role of dopamine in the nucleus
accumbens during operant ethanol self‐administration by separating bar pressing (ethanol …