Background: Iron is critical for fundamental biologic functions such as cell division and
mitochondrial electron transport. However, by the virtue of its ability to donate electrons, iron …

Iron is required for key aspects of cellular physiology including mitochondrial function and
DNA synthesis and repair. However, free iron is an aberration because of its ability to donate …

Iron-mediated oxidative stress is implicated in the pathogenesis of renal ischemia–
reperfusion injury. Hepcidin is an endogenous acute phase hepatic hormone that prevents …

Iron is an essential metal involved in several major cellular processes required to maintain
life. Because of iron's ability to cause oxidative damage, its transport, metabolism, and …

Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with
limited available interventions. Host iron acquisition by pathogens and systemic …

Acute kidney injury (AKI) is a very common condition with high morbidity and mortality, which
can be seen in 5–7% of all hospitalized patients and in up to 57% of all intensive care unit …

Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to
ferroportin-1 (FPN1) and inducing its internalization and degradation, acts as the critical …

The effects of ferroptosis, an iron-dependent cell death, on acute respiratory distress
syndrome (ARDS) remain largely elusive. Hepcidin, encoded by the HAMP gene, affects …

Oxidative stress is a major contributor to kidney injury following ischemia reperfusion.
Ferritin, a highly conserved iron-binding protein, is a key protein in the maintenance of …

Iron is an essential element for all living organisms, but produces toxic oxidants. Thus, iron
homeostasis is tightly regulated in mammals. Hepcidin-25 (hepcidin) has emerged as a …