Nitric oxide (NO) is a short-lived pleiotropic regulator and is required for numerous
pathophysiological functions, including macrophage-mediated immunity and cancer. It is a …

Nitric oxide (NO) is involved in various physiological functions and its role in tumorigenesis
has been well studied. A large majority of human and experimental tumors appear to …

Nitric oxide (NO) is a pleiotrophic regulator, pivotal to numerous biological processes,
including vasodilation, neurotransmission, and macrophage-mediated immunity. The highly …

Abstract Cyclooxygenase (COX)‐2 has been suggested to play an important role in colon
carcinogenesis. We found that the COX‐2 selective inhibitor, nimesulide, reduces …

NO (nitric oxide) biology has provided the impetus for the development of anticancer agents
based on their ability to release NO. NO-NSAIDs (NO-donating non-steroidal anti …

Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy
remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its …

Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs), consisting of a
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …

Significance: Gastrointestinal (GI) cancer taken together constitutes one of the most common
cancers worldwide with a broad range of etiological mechanisms. In this review, we have …

Nitric oxide synthases (NOS) are a family of isoforms, which generate nitric oxide (NO). NO
is one of the smallest molecules in nature and acts mainly as a potent vasodilator. It …

Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the
role of NO is decided by its concentration present in physiological environments. NO either …