Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer
biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors with
an overall five-year survival rate of that has only just reached 10%. The tumor …

Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide
due to late diagnosis and early metastasis, with a 1-year overall survival rate of …

The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's
research team made many efforts on revealing the oncogenic function of hypoxic inducible …

One of the key factors that correlates with poor survival of patients with pancreatic cancer is
the extent of hypoxic areas within the tumor tissue. The adaptation of pancreatic cancer cells …

Hypoxia is known to play critical roles in cell survival, angiogenesis, tumor invasion, and
metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been …

Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …

Hypovasculature is an outstanding characteristic of pancreatic cancers in imaging
diagnosis, suggesting that blood supply is poor in pancreatic cancer tissues. Despite poor …