Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to
cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor …

Background Pancreatic cancer is one of the representative solid tumors, in which the
hypoxic microenvironment plays a crucial role in malignant progression. We previously …

Hypoxia is a microenvironmental factor which plays a critical role in tumor development and
chemoresistance. Epithelial-to-mesenchymal transition (EMT) induced by hypoxia is one of …

Background Intratumoral hypoxia and epithelial–mesenchymal transition are involved in
tumor invasion and metastasis. Aims This study investigated the molecular mechanisms that …

Background Pancreatic cancer is a devastating disease that is characterized by persistent
hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α …

In the tumor cells exposed to hypoxia, hypoxia-inducible factor-1 (HIF-1)-mediated
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …

The hypoxic environment in tumor is reported to play an important role in pancreatic cancer
progression. The interaction between stromal and cancer cells also contributes to the …

Hypoxia is an important feature of the tumor microenvironment, and is closely associated
with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these …

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …