Simple Summary Low oxygen tension (hypoxia) caused by high demand of cancer cell
proliferation or standard of care therapy is a prevalent feature of solid tumors and is often …

Hypoxia is a potent microenvironmental factor that promotes tumor metastasis. Recent
studies have revealed mechanisms by which hypoxia and activation of hypoxia inducible …

BACKGROUND Pancreatic cancer (PC) is one of the deadliest cancers worldwide. PC
metastasis involves a complex set of events, including epithelial-mesenchymal transition …

Intratumoral hypoxia is a widely established element of the pancreatic tumor
microenvironment (TME) promoting immune escape, tumor invasion, and progression, while …

Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited
therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation …

Tumors use several strategies to evade the host immune response, including creation of an
immune-suppressive and hostile tumor environment. Tissue hypoxia due to inadequate …

A solid tumour forms an organ-like structure that is comprised of cancer cells as well as
stroma cells (fibroblasts, inflammatory cells) that are embedded in an extracellular matrix …

Background Diabetes mellitus and pancreatic cancer are intimately related. Our previous
studies showed that high levels of blood glucose promote epithelial-mesenchymal transition …

Hypoxia in solid tumors is associated with treatment resistance and increased metastatic
potential. Although hypoxia has been reported in pancreatic cancer patients, there is little …