Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

Hypoxia is involved in the development of pancreatic cancer (PC). The responses of hypoxia‐
associated genes and their regulated mechanisms are largely unknown. In this study …

Hypoxic microenvironments frequently exist in many solid tumours with oxygen levels
fluctuating temporally and spatially from normoxia to hypoxia. The response to hypoxia in …

Metastasis is responsible for more than 90% of deaths among cancer patient. It is a highly
complex process that involves the interplay between cancer cells, the tumor …

Since the first identification of hypoxic cells in sections of carcinomas in the 1950s, hypoxia
has been known as a central hallmark of cancer cells and their microenvironment. Indeed …

Metabolic alterations are one of the hallmarks of cancer, which has recently gained great
attention. Increased glucose absorption and lactate secretion in cancer cells are …

Hypoxia has been recognized as one of the fundamentally important features of solid tumors
and plays a critical role in various cellular and physiologic events, including cell …

Hypoxia in locally advanced solid tumors develops due to uncontrollable cell proliferation,
altered metabolism, and the severe structural and functional abnormality of the tumor …

Hypoxia is a common feature of malignant tumors. There is an interactive connection
between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis …

Breast cancer has been the leading cause of female cancer deaths for decades. Intratumoral
hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is …