Aim The main objective is to review the available evidence in the literature for
developmental origins of neuropsychiatric diseases and their underlying mechanisms. We …

Adverse intrauterine events may profoundly impact fetal risk for future adult diseases. The
mechanisms underlying this increased vulnerability are complex and remain poorly …

Converging evidence from clinical and preclinical studies suggests that fetal vulnerability to
adverse prenatal exposures increases the risk for neuropsychiatric diseases such as autism …

Preterm birth (PTB) is a leading cause of neurodevelopmental and neurocognitive
impairment in childhood and is closely associated with psychiatric disease. The biological …

The prenatal period is increasingly considered as a crucial target for the primary prevention
of neurodevelopmental and psychiatric disorders. Understanding their pathophysiological …

Brain development during the prenatal period is rapid and unparalleled by any other time
during development. Biological systems undergoing rapid development are at higher risk for …

Heightened psychological stress during pregnancy has repeatedly been associated with
increased risk for development of behavior problems and psychiatric disorders in offspring …

Epidemiologic studies have, for many years, identified preterm birth as a significant risk
factor for psychiatric disorders. There has been a recent resurgence of interest in …

This chapter critically examines the hypothesis that the origins of some adult mental
illnesses such as schizophrenia, which is the focus of this review, derive from adverse …

Background There is increasing understanding of the significance of early
neurodevelopment in establishing risk for the range of mental disorders. Models of the early …