Extracellular phosphorylation converts pigment epithelium–derived factor from a neurotrophic to an antiangiogenic factor

G Maik-Rachline, S Shaltiel, R Seger - Blood, 2005 - ashpublications.org
The pigment epithelium–derived factor (PEDF) belongs to the superfamily of serine protease
inhibitors (serpin). There have been 2 distinct functions attributed to this factor, which can act …

Variable phosphorylation states of pigment-epithelium–derived factor differentially regulate its function

G Maik-Rachline, R Seger - Blood, 2006 - ashpublications.org
The pigment epithelium–derived factor (PEDF) belongs to the family of noninhibitory serpins.
Although originally identified in the eye, PEDF is widely expressed in other body regions …

Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization

SV Petersen, Z Valnickova, JJ Enghild - Biochemical Journal, 2003 - portlandpress.com
Pigment epithelium-derived factor (PEDF) inhibits the formation of blood vessels in the eye
by inducing apotosis in actively dividing endothelial cells. The activity of PEDF equals or …

Pedf a noninhibitory serpin with neurotrophic activity

NI Minkevich, VM Lipkin… - Acta Naturae …, 2010 - cyberleninka.ru
The pigment epithelium-derived factor (PEDF) is a glycoprotein with a molecular weight of
50 kDa belonging to the noninhibitory serpin family. It regulates several physiological …

Characterization of PEDF: a multi‐functional serpin family protein

S Filleur, T Nelius, W De Riese… - Journal of cellular …, 2009 - Wiley Online Library
Pigment epithelium‐derived factor (PEDF) is a 50 kDa secreted glycoprotein that belongs to
the non‐inhibitory serpin family group. PEDF has been described as a natural angiogenesis …

Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor

L Notari, V Baladron, JD Aroca-Aguilar, N Balko… - Journal of biological …, 2006 - ASBMB
Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein
belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic …

Recombinant human pigment epithelium‐derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells

E Stratikos, E Alberdi, PGW Gettins… - Protein …, 1996 - Wiley Online Library
Pigment epithelium‐derived factor (PEDF) is a serpin found in the interphotoreceptor matrix
of the eye, which, although not a proteinase inhibitor, possesses a number of important …

How PEDF prevents angiogenesis: a hypothesized pathway

JG Ren, C Jie, C Talbot - Medical hypotheses, 2005 - Elsevier
Pigment epithelium-derived factor (PEDF) is a multiple functional protein, coded by the
serine proteinase inhibitor, clade F, member 1 (SERPINF1) gene, which has both anti …

Pigment epithelium-derived factor: a multimodal tumor inhibitor

ETH Ek, CR Dass, PFM Choong - Molecular cancer therapeutics, 2006 - AACR
Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serine protease
inhibitor (serpin) family, is a well-known potent endogenous inhibitor of angiogenesis. It has …

Pigment epithelium-derived factor (PEDF), a serpin with potent anti-angiogenic and neurite outgrowth-promoting properties

PGW Gettins, M Simonovic, K Volz - 2002 - degruyter.com
Pigment epitheliumderived factor is a member of the serpin superfamily of proteins, but one
that lacks inhibitory properties against either serine or cysteine proteinases. Nevertheless it …