DNA methylation on CpG sites is the most common epigenetic modification. Recently,
methylation in a non-CpG context was found to occur widely on genomic DNA. Moreover …

Background DNA methylation in promoters is closely linked to downstream gene repression.
However, whether DNA methylation is a cause or a consequence of gene repression …

Understanding the molecular principles governing interactions between transcription factors
(TFs) and DNA targets is one of the main subjects for transcriptional regulation. Recently …

Epigenetic DNA modification impacts gene expression, but the underlying molecular
mechanisms are only partly understood. Adding a methyl group to a cytosine base locally …

Many anecdotal observations exist of a regulatory effect of DNA methylation on gene
expression. However, in general, the underlying mechanisms of this effect are poorly …

DNA methylation, especially CpG methylation at promoter regions, has been generally
considered as a potent epigenetic modification that prohibits transcription factor (TF) …

INTRODUCTION Nearly all cells in the human body share the same primary genome
sequence consisting of four nucleotide bases. One of the bases, cytosine, is commonly …

Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …

DNA methylation is an important epigenetic mechanism for gene regulation. The
conventional view of DNA methylation is that DNA methylation could disrupt protein-DNA …

Abstract Background While methylation of CpG dinucleotides is traditionally considered
antagonistic to the DNA-binding activity of most transcription factors (TFs), recent in vitro …