The tendency of individual CpG sites to be methylated is distinctive, non-random and well-
regulated throughout the genome. We investigated the structural and spatial factors …

Cell identity is determined by the chromatin structure and profiles of gene expression, which
are dependent on chromatin accessibility and DNA methylation of the regions critical for …

DNA methylation: A molecular lock: Current Biology Skip to Main Content Advertisement Current
Biology This journal offers authors two options (open access or subscription) to publish research …

Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …

DNA methylation in the genome plays a fundamental role in the regulation of gene
expression and is widespread in the genome of eukaryotic species. For example, in higher …

Methylation of CpG dinucleotides is an epigenetic mechanism involved in the regulation of
gene expression in mammals. The patterns of CpG methylation are specie and tissue …

Background Cardiovascular disease (CVD) is the leading cause of death worldwide and
considered one of the most environmentally driven diseases. The role of DNA methylation in …

Background DNA methylation is thought to play an important role in the regulation of
mammalian gene expression, partly based on the observation that a lack of CpG island …