Toll-like receptors: promising therapeutic targets for inflammatory diseases
The health of living organisms is constantly challenged by bacterial and viral threats. The
recognition of pathogenic microorganisms by diverse receptors triggers a variety of host …
recognition of pathogenic microorganisms by diverse receptors triggers a variety of host …
Toll-like receptors as potential therapeutic targets for multiple diseases
C Zuany-Amorim, J Hastewell, C Walker - Nature Reviews Drug …, 2002 - nature.com
The family of Toll-like receptors (TLRs) is receiving considerable attention as potential
regulators and controllers of the immune response through their ability to recognize …
regulators and controllers of the immune response through their ability to recognize …
Role of Toll-like receptors in infection and immunity: clinical implications
P Cristofaro, SM Opal - Drugs, 2006 - Springer
The remarkable discovery of the Toll-like receptors (TLRs) over the past 5 years has opened
up an entirely new era in the understanding of the molecular events that initiate the …
up an entirely new era in the understanding of the molecular events that initiate the …
Toll-like receptors as a therapeutic target in the era of immunotherapies
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …
foreign and host molecules in order to initiate the immune response. They play a crucial role …
Toll-like receptors activation, signaling, and targeting: an overview
SR El-Zayat, H Sibaii, FA Mannaa - Bulletin of the National Research …, 2019 - Springer
Abstract Background Toll-like receptors (TLRs) are an important family of receptors that
constitute the first line of defense system against microbes. They can recognize both …
constitute the first line of defense system against microbes. They can recognize both …
Toll-like receptors as targets for immune disorders
B Keogh, AE Parker - Trends in Pharmacological Sciences, 2011 - cell.com
Since the identification of the first Toll-like receptor (TLR) in humans in 1997, understanding
of the molecular basis for innate immunity has increased significantly. The TLR family and …
of the molecular basis for innate immunity has increased significantly. The TLR family and …
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
LAJ O'Neill - Current opinion in pharmacology, 2003 - Elsevier
Roles for Toll-like receptors (TLRs) are emerging in conditions such as sepsis syndrome,
systemic lupus erythromatosis, rheumatoid arthritis and asthma, suggesting that the …
systemic lupus erythromatosis, rheumatoid arthritis and asthma, suggesting that the …
Toll-like receptor signaling: emerging opportunities in human diseases and medicine
RN Bhattacharjee, S Akira - Current Immunology Reviews, 2005 - ingentaconnect.com
The family of Toll-like receptors (TLR1-TLR11) provides host defense in mammals by
inducing proinflammatory innate immune response upon recognition of conserved structural …
inducing proinflammatory innate immune response upon recognition of conserved structural …
The significance of toll-like receptors in human diseases
MTM Vega, A de Andrés Martín - Allergologia et immunopathologia, 2009 - Elsevier
Toll-like receptors (TLRs) are a family of transmembrane receptors that have been
preserved throughout evolution and which selectively recognize a broad spectrum of …
preserved throughout evolution and which selectively recognize a broad spectrum of …
Toll‐like receptors: Role in inflammation and therapeutic potential
E Kay, RS Scotland, JR Whiteford - Biofactors, 2014 - Wiley Online Library
Inflammation is an essential process in response to injury and infection. However, under
certain circumstances dis‐regulation of this process can lead to pathologies such as …
certain circumstances dis‐regulation of this process can lead to pathologies such as …