Alcohol addiction is a disease that includes a diverse set of phenotypes. Functional alcohol
tolerance is an adaptation to the effects of alcohol that restores neuronal homeostatic …

Alcohol abuse is a pervasive problem known to be influenced by genetic factors, yet our
understanding of the mechanisms underlying alcohol addiction is far from complete …

To understand the molecular and neural mechanisms underlying alcohol addiction, many
models ranging from vertebrates to invertebrates have been developed. In Drosophila …

Drosophila melanogaster is commonly found near rotting or fermenting fruit, reflected in its
name pomace, or vinegar fly. In such environments, flies often encounter significant levels of …

Background: Ethanol tolerance, defined as a reduction in the intensity of the effects of
ethanol upon continuous or repeated exposure, is a hallmark of alcoholism. Tolerance may …

Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

Alcohol abuse is a serious problem in most societies. The economic and medical costs
associated with alcohol abuse extend into billions of dollars in the United States alone …

Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

In free nature, animals rarely become alcoholics. Only when humans interfere do they
develop some aspects of dependence. In humans, it is thought that 40–60% of the risk to …

Our understanding of alcohol use disorder (AUD), particularly alcohol's effects on the
nervous system, has unquestionably benefited from the use of model systems such as …