Abnormal calcium (Ca) handling can contribute to arrhythmogenesis directly by triggering
abnormal depolarizations and indirectly by modulating action potential time course and …

Under several types of conditions, reversal of steps of excitation–contraction coupling
(RECC) can give rise to nondriven electrical activity. In this review we explore those …

Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling.
Intracellular Ca2+ concentration increases during systole and falls in diastole thereby …

Congestive heart failure is the leading cause of death in the Western world. Abnormal
intracellular calcium (Ca2+) handling is central to the pathogenesis of heart failure because …

Cardiac arrhythmia is an important cause of death in patients with heart failure (HF) and
inherited arrhythmia syndromes, such as catecholaminergic polymorphic ventricular …

Ventricular arrhythmias deteriorating into sudden cardiac death are a major cause of
mortality worldwide. The recent linkage of a genetic form of cardiac arrhythmia to mutations …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Alterations of intracellular Ca2+ handling in hypertrophied myocardium have been proposed
as a mechanism of ventricular tachyarrhythmias, which are a major cause of sudden death …

Calcium Cycling in Heart Failure. Ventricular tachycardia in nonischemic heart failure (HF)
arises from a nonreentrant mechanism most likely due to delayed afterdepolarizations from …

Dysfunctional sarcoplasmic reticulum Ca2+ handling is commonly observed in heart failure,
and thought to contribute to arrhythmogenesis through several mechanisms. Some time ago …