The discovery of promising cytokines and clarification of their immunological mechanisms in
controlling the intracellular fate of Mycobacterium tuberculosis (Mtb) are necessary to …

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis
survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) …

The long-term control of tuberculosis (TB) will require the development of more effective anti-
TB vaccines, as the only licensed vaccine, Mycobacterium bovis bacille Calmette-Guérin …

Mast Cells (MCs) express toll-like receptor 2 (TLR2), a receptor known to be triggered by
several major mycobacterial ligands and involved in resistance against Mycobacterium …

The macrophage is the niche of the intracellular pathogen Mycobacterium tuberculosis.
Induction of macrophage apoptosis by CD4+ or CD8+ T cells is accompanied by reduced …

Macrophages mediate the first line of defense in the host against various intracellular
pathogens. They are armed with several immune-effector mechanisms to detect and combat …

Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis, is an
intracellular bacterium capable of surviving and persisting within host mononuclear cells …

Highlights•TLR2 does not contribute to protection against acute Mtb infection.•TLR2 has a
significant role in protection against chronic Mtb infection.•TLR2 controls immunopathology …

As a hallmark of tuberculosis (TB), Mycobacterium tuberculosis (MTB) induces
granulomatous lung lesions and systemic inflammatory responses during active disease …

The unique PE/PPE multigene family of proteins occupies almost 10% of the coding
sequence of Mycobacterium tuberculosis (M. tb), the causative agent of human tuberculosis …