Background Protein interaction databases often provide confidence scores for each
recorded interaction based on the available experimental evidence. Protein interaction …

Background As numerous experimental factors drive the acquisition, identification, and
interpretation of protein-protein interactions (PPIs), aggregated assemblies of human PPI …

Motivation: Experimental limitations in high-throughput protein–protein interaction detection
methods have resulted in low quality interaction datasets that contained sizable fractions of …

Motivation: Recent screening techniques have made large amounts of protein–protein
interaction data available, from which biologically important information such as the function …

Background This paper describes an automated method for finding clusters of
interconnected proteins in protein interaction networks and retrieving protein annotations …

Abstract Knowledge of all molecular interactions that potentially take place in the cell is a
key for a detailed understanding of cellular processes. Currently available interaction data …

High-throughput experimental methods, such as yeast-two-hybrid and phage display, have
fairly high levels of false positives (and false negatives). Thus the list of protein-protein …

The biological significance of protein interactions, their method of generation and reliability
is briefly reviewed. Protein interaction networks adopt a scale-free topology that explains …

High-throughput protein interaction data, with ever-increasing volume, are becoming the
foundation of many biological discoveries. However, high-throughput protein interaction …

Background and contribution In network biology, molecular functions can be characterized
by network-based inference, or “guilt-by-associations.” PageRank-like tools have been …