Molecular Docking and Molecular Dynamic Investigations of Xanthone-Chalcone Derivatives against Epidermal Growth Factor Receptor for Preliminary Discovery of …

YS Kurniawan, E Yudha, G Nugraha… - Indonesian Journal of …, 2024 - journal.ugm.ac.id
Epidermal growth factor receptor (EGFR) is found to be overexpressed in cancer cells as it
controls angiogenesis, cell signaling, and proliferation mechanisms. Therefore, EGFR has …

Molecular Docking Approach For Design and Synthesis of Thioxanthone Derivatives as Anticancer Agents

F Hermawan, Jumina, HD Pranowo… - …, 2022 - Wiley Online Library
Thioxanthone derivatives were docked, synthesized, and tested for their anticancer activity.
The molecular docking results showed that 1‐hydroxythioxanthone, 2‐chloro‐1 …

Molecular docking studies and ADME predictions on synthesized chalcone compounds targeting EGFR

Ö Gündoğdu - Hittite Journal of Science and Engineering, 2023 - dergipark.org.tr
In the present study, new chalcone derivatives (5a–5f) obtained from the condensation
reaction of cuminaldehyde and acetophenone compounds containing different substituents …

[HTML][HTML] Molecular docking based screening of novel designed chalcone series of compounds for their anti-cancer activity targeting EGFR kinase domain

CMMP Rao, RP Yejella, RSA Rehman, SH Basha - Bioinformation, 2015 - ncbi.nlm.nih.gov
Epidermal growth factor receptors (EGFR) are critical for the growth of many tumors and
expressed at high levels in about one third of epithelial cancers. Hence, blockade of the …

Molecular Docking Analysis of Hydroxy Chalcones and Flavones from Anisaldehyde and Veratraldehyde as EGFR Inhibitors: Predicting Anticancer Potential

W Pambudi, W Haryadi, S Matsjeh, C Anwar - Molekul, 2024 - jos.unsoed.ac.id
This study aimed to investigate the potential of hydroxy chalcone and flavone derivatives as
inhibitors of the epidermal growth factor receptor (EGFR) with anticancer properties …

[PDF][PDF] Design of thioxanthone derivatives as potential tyrosine kinase inhibitor: A molecular docking study

F Hermawan, J Jumina, HD Pranowo - Rasayan J. Chem, 2020 - academia.edu
Xanthone derivatives have been well-known for their wide and outstanding bioactivity so far.
However, investigation of thioxanthone derivatives and their biological activity is rarely …

Synthesis, Cytotoxicity Evaluation and Molecular Docking Studies of Xanthyl-Cinnamate Derivatives as Potential Anticancer Agents

MR Iresha, J Jumina, HD Pranowo… - Indonesian Journal of …, 2022 - journal.ugm.ac.id
A new series of xanthyl-cinnamate hybrid compounds (4a-d) have been synthesized and
screened through in vitro assay against four human cancer cell lines, ie, HeLa, T47D, A549 …

[HTML][HTML] In-vitro cytotoxicity and in-silico investigation of the anticancer potential of 3-methoxyxanthen-9-one from Garcinia lanceifolia Roxb

MA Hossain, SK Mahato, MS Rana - Informatics in Medicine Unlocked, 2023 - Elsevier
For its beneficial effects on health, Garcinia lanceifolia Roxb. Has long been used as a
vegetable and in juice. In this study, as part of the process of finding and developing new …

[HTML][HTML] Insights from molecular modeling, docking and simulation of imidazole nucleus containing chalcones with EGFR kinase domain for improved binding function

GE Rao, SA Rahaman, AP Rani - Bioinformation, 2016 - ncbi.nlm.nih.gov
EGFR Kinase domain is a crucial role player cell surface receptor protein activated by
specific binding of its ligand like EGFR. Importance of this protein as a therapeutically …

In vitro and in silico studies of quercetin and daidzin as selective anticancer agents

MS Zubair, S Anam, S Maulana… - Indonesian Journal of …, 2021 - journal.ugm.ac.id
Quercetin and daidzin are flavonoid and flavonoid glycoside type compounds that have
been found in many plants and nutraceuticals. This study aims to examine the in vitro …