CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF‐β signaling

T Taki, Y Shiraki, A Enomoto, L Weng, C Chen… - Cancer …, 2020 - Wiley Online Library
Stromal invasion is considered an important prognostic factor in patients with lung
adenocarcinoma. The mechanisms underlying the formation of tumor stroma and stromal …

Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling

KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin… - Cancer …, 2020 - Wiley Online Library
Lung cancer is the most commonly diagnosed cancer worldwide, and metastasis in lung
cancer is the leading cause of cancer‐related deaths. Thus, understanding the mechanism …

[HTML][HTML] CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines

Y Piao, H Guo, Z Qu, B Zheng… - Oncology Letters, 2019 - spandidos-publications.com
Dysregulated expression of the cell surface protein, CD146, has been implicated in various
types of cancer in humans, including in lung cancer. The present study aimed to clarify the …

The analysis of multiple omics and examination of pathological images revealed the prognostic and therapeutic significances of CD93 in lung squamous cell …

J Qu, L Lin, G Fu, M Zheng, J Geng, X Sun, L Xing - Life Sciences, 2024 - Elsevier
As a potent pro-angiogenic factor, the role of CD93 in the prognosis and therapeutic
outcomes of lung squamous cell carcinoma (LUSC) merits exploration. In this study, we …

CD109 and squamous cell carcinoma

R Qi, F Dong, Q Liu, Y Murakumo, J Liu - Journal of Translational …, 2018 - Springer
Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor
prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein …

CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro

S Zhou, SD da Silva, PM Siegel, A Philip - Scientific Reports, 2019 - nature.com
There is increasing evidence that the expression of CD109, a GPI-anchored cell surface
protein is dysregulated in squamous cell carcinoma (SCC). However, the functional role of …

Upregulation of CD109 promotes the epithelial-to-mesenchymal transition and stemness properties of lung adenocarcinomas via activation of the hippo-YAP signaling

KY Lee, TC Kuo, CM Chou, WJ Hsu, WC Lee, JZ Dai… - Cells, 2020 - mdpi.com
Metastasis is the leading cause of death in lung adenocarcinomas. Identifying potential
prognostic biomarkers and exploiting regulatory mechanisms could improve the diagnosis …

High‐level expression of CD109 is frequently detected in lung squamous cell carcinomas

T Sato, Y Murakumo, S Hagiwara, M Jijiwa… - Pathology …, 2007 - Wiley Online Library
CD109 is a glycosylphosphatidylinositol (GPI)‐anchored cell surface protein, which is a
member of the α2‐macroglobulin/C3, C4, C5 family of thioester‐containing proteins. It has …

CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma

XT Mo, THY Leung, HWM Tang, MKY Siu… - British Journal of …, 2020 - nature.com
Background CD109 was involved in the tumorigenesis and progression of various cancers
via TGF-β1 signalling and STAT3 activation. As CD109 is strongly expressed in cervical …

CD109 is a critical determinant of EGFR expression and signaling, and tumorigenicity in squamous cell carcinoma cells

S Zhou, A Hassan, T Kungyal, S Tabariès, JLRG Luna… - Cancers, 2022 - mdpi.com
Simple Summary Squamous cell carcinoma is a type of cancer resulting from cancer of the
squamous cells that line some organs of the body such as the skin, lungs, and vulva. It is …