CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF‐β signaling
Stromal invasion is considered an important prognostic factor in patients with lung
adenocarcinoma. The mechanisms underlying the formation of tumor stroma and stromal …
adenocarcinoma. The mechanisms underlying the formation of tumor stroma and stromal …
Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling
KY Lee, PW Shueng, CM Chou, BX Lin, MH Lin… - Cancer …, 2020 - Wiley Online Library
Lung cancer is the most commonly diagnosed cancer worldwide, and metastasis in lung
cancer is the leading cause of cancer‐related deaths. Thus, understanding the mechanism …
cancer is the leading cause of cancer‐related deaths. Thus, understanding the mechanism …
[HTML][HTML] CD146 promotes migration and proliferation in pulmonary large cell neuroendocrine carcinoma cell lines
Y Piao, H Guo, Z Qu, B Zheng… - Oncology Letters, 2019 - spandidos-publications.com
Dysregulated expression of the cell surface protein, CD146, has been implicated in various
types of cancer in humans, including in lung cancer. The present study aimed to clarify the …
types of cancer in humans, including in lung cancer. The present study aimed to clarify the …
The analysis of multiple omics and examination of pathological images revealed the prognostic and therapeutic significances of CD93 in lung squamous cell …
J Qu, L Lin, G Fu, M Zheng, J Geng, X Sun, L Xing - Life Sciences, 2024 - Elsevier
As a potent pro-angiogenic factor, the role of CD93 in the prognosis and therapeutic
outcomes of lung squamous cell carcinoma (LUSC) merits exploration. In this study, we …
outcomes of lung squamous cell carcinoma (LUSC) merits exploration. In this study, we …
CD109 and squamous cell carcinoma
Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor
prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein …
prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein …
CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro
There is increasing evidence that the expression of CD109, a GPI-anchored cell surface
protein is dysregulated in squamous cell carcinoma (SCC). However, the functional role of …
protein is dysregulated in squamous cell carcinoma (SCC). However, the functional role of …
Upregulation of CD109 promotes the epithelial-to-mesenchymal transition and stemness properties of lung adenocarcinomas via activation of the hippo-YAP signaling
KY Lee, TC Kuo, CM Chou, WJ Hsu, WC Lee, JZ Dai… - Cells, 2020 - mdpi.com
Metastasis is the leading cause of death in lung adenocarcinomas. Identifying potential
prognostic biomarkers and exploiting regulatory mechanisms could improve the diagnosis …
prognostic biomarkers and exploiting regulatory mechanisms could improve the diagnosis …
High‐level expression of CD109 is frequently detected in lung squamous cell carcinomas
T Sato, Y Murakumo, S Hagiwara, M Jijiwa… - Pathology …, 2007 - Wiley Online Library
CD109 is a glycosylphosphatidylinositol (GPI)‐anchored cell surface protein, which is a
member of the α2‐macroglobulin/C3, C4, C5 family of thioester‐containing proteins. It has …
member of the α2‐macroglobulin/C3, C4, C5 family of thioester‐containing proteins. It has …
CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma
XT Mo, THY Leung, HWM Tang, MKY Siu… - British Journal of …, 2020 - nature.com
Background CD109 was involved in the tumorigenesis and progression of various cancers
via TGF-β1 signalling and STAT3 activation. As CD109 is strongly expressed in cervical …
via TGF-β1 signalling and STAT3 activation. As CD109 is strongly expressed in cervical …
CD109 is a critical determinant of EGFR expression and signaling, and tumorigenicity in squamous cell carcinoma cells
S Zhou, A Hassan, T Kungyal, S Tabariès, JLRG Luna… - Cancers, 2022 - mdpi.com
Simple Summary Squamous cell carcinoma is a type of cancer resulting from cancer of the
squamous cells that line some organs of the body such as the skin, lungs, and vulva. It is …
squamous cells that line some organs of the body such as the skin, lungs, and vulva. It is …