Background Early appropriate antibiotic treatment is essential in sepsis. We aimed to
evaluate the impact of a multifaceted educational intervention to improve antibiotic …

Introduction In patients with severe sepsis and septic shock as cause of Intensive Care Unit
(ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy …

Methods A retrospective case note review was performed, looking at a sample of 5,954
patients who were 18 years or older who had been admitted to East Surrey Hospital (ESH) …

Introduction Although early institution of adequate antimicrobial therapy is lifesaving in
sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the …

Introduction Recent models capturing the pathophysiology of sepsis and ex-vivo data from
patients are speculating about immunosuppression in the so-called late phase of sepsis …

Background Sepsis is common, deadly, and heterogenous. Prior analyses of patients with
sepsis and septic shock in New York State showed a risk-adjusted association between …

Background De-escalation is strongly recommended for antibiotic stewardship. No studies
have addressed this issue in the context of health care-associated intra-abdominal …

Methods We conducted a prospective audit of consecutive patients with severe sepsis
admitted to an ITU between February and June 2010. The patients were identified as those …

Background Antibiotic exposure in intensive care patients with sepsis is frequently
inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the …

Introduction Due to the increasing burden on hospital systems, most elderly patients with
non-surgical sepsis are admitted to general internal medicine departments. Disease-severity …