We read with great interest the correspondence letters of Salles et al.[1] and Stip et al.[2],
following our multicenter observational retrospective study that showed a substantial …

The acid sphingomyelinase (ASM)/ceramide system may provide a useful framework for
better understanding SARS-CoV-2 infection and the repurposing of psychotropic …

Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide,
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …

Prior evidence indicates the potential central role of the acid sphingomyelinase
(ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a …

To reduce Coronavirus Disease 2019 (COVID-19)-related mortality and morbidity, widely
available oral COVID-19 treatments are urgently needed. Certain antidepressants, such as …

Several medications commonly used for a number of medical conditions share a property of
functional inhibition of acid sphingomyelinase (ASM), or FIASMA. Preclinical and clinical …

The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral
infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase …

SARS-CoV-2 variants such as the delta or omicron variants, with higher transmission rates,
accelerated the global COVID-19 pandemic. Thus, novel therapeutic strategies need to be …

In a large, multicenter, retrospective cohort study of 83 584 patients with laboratory-
confirmed COVID-19 who had an emergency department or urgent care visit or were …

Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce.
Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive …