Parsing structural fragments of thiazolidin-4-one based α-amylase inhibitors: A combined approach employing in vitro colorimetric screening and GA-MLR based …
Abstract α-Amylase (EC. 3.2. 1.1) is a ubiquitous digestive endoamylase. The abrupt rise in
blood glucose levels due to the hydrolysis of carbohydrates by α-amylase at a faster rate is …
blood glucose levels due to the hydrolysis of carbohydrates by α-amylase at a faster rate is …
Exploring biological efficacy of novel benzothiazole linked 2, 5-disubstituted-1, 3, 4-oxadiazole hybrids as efficient α-amylase inhibitors: Synthesis, characterization …
In an effort to explore a class of novel antidiabetic agents, we have made an effort to
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor
In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
Design of novel benzimidazole derivatives as potential α-amylase inhibitors using QSAR, pharmacokinetics, molecular docking, and molecular dynamics simulation …
In the present study, a quantitative relationship between the biological inhibitory activity of
alpha-amylase and molecular structures of novel benzimidazole derivatives is analyzed in …
alpha-amylase and molecular structures of novel benzimidazole derivatives is analyzed in …
Identification of potential N-substituted 5-benzylidenethiazolidine-2, 4‑dione derivatives as α-amylase inhibitors: Computational cum synthetic studies
Diabetes mellitus is a chronic metabolic disorder become a major health problem globally
associated with social and economic consequences. α-amylase is an endo-amylase …
associated with social and economic consequences. α-amylase is an endo-amylase …
CORAL: probing the structural requirements for α-amylase inhibition activity of 5-(3-arylallylidene)-2-(arylimino) thiazolidin-4-one derivatives based on QSAR with …
The present study aims to examine the structural requirements governing α-amylase
inhibitory activity of 5-(3-arylallylidene)-2-(arylimino) thiazolidin-4-one derivatives and their …
inhibitory activity of 5-(3-arylallylidene)-2-(arylimino) thiazolidin-4-one derivatives and their …
Computational study of 2-aryl quinoxaline derivatives as α-amylase inhibitors
A computational analysis combining 3D-QSAR modeling, molecular docking, and
pharmacokinetic properties (ADMET), led to the discovery of novel ligands with potent …
pharmacokinetic properties (ADMET), led to the discovery of novel ligands with potent …
Design of novel benzimidazole derivatives as potential α-amylase inhibitors by 3D-QSAR modeling and molecular docking studies
K El Khatabi, I Aanouz, R El-Mernissi… - Journal of the Turkish …, 2020 - dergipark.org.tr
The enzyme α-amylase belongs to the highly conserved glycoside hydrolase family which is
regarded as a good target for the discovery of antidiabetic agents. Following a 3D-QSAR …
regarded as a good target for the discovery of antidiabetic agents. Following a 3D-QSAR …
Recent developments in the synthesis of N‐heterocyclic compounds as α‐amylase inhibitors via in‐vitro and in‐silico analysis: Future drugs for treating diabetes
In nature, N‐heterocyclic compounds and their derivatives are abundant. They serve as the
building blocks of many biological entities, such as enzymes, alkaloids, hormones …
building blocks of many biological entities, such as enzymes, alkaloids, hormones …
Quantitative structure activity relationship studies of novel hydrazone derivatives as α-amylase inhibitors with index of ideality of correlation
The present manuscript describes the synthesis, α-amylase inhibition, in silico studies and in-
depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones …
depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones …