Women at very high risk for having a child with a neural tube defect (NTD) because they had
previously delivered affected children significantly reduced their recurrence rate by taking …

Objective In 1991, the Medical Research Council (MRC) Vitamin Study demonstrated that
folic acid taken before pregnancy and in early pregnancy reduced the risk of a neural tube …

Neural tube defects (NTDs) are common birth defects and contribute to life-long disabilities,
high medical care costs, and perinatal and child mortality. This review is a primer on …

The maternal vitamin status, especially of folate, is involved in the pathogenesis of neural-
tube defects (NTDs). Maternal folate administration can prevent these malformations. The …

Randomized trials, supported by many observational studies, have shown that
periconceptional use of folic acid, alone or in multivitamin supplements, is effective for the …

Neural tube defects (NTDs) are common fetal malformations. They are multifactorial in
origin, with folic acid as the primary known environmental factor. It is recommended that all …

Neural tube defects (NTDs) are multifactorial in their etiology, having both genetic and
environmental factors contributing to their development. Recent evidence demonstrates that …

Neural tube closure takes place during early embryogenesis and requires interactions
between genetic and environmental factors. Failure of neural tube closure is a common …

Risk of neural tube defects (NTDs) is determined by genetic and environmental factors,
among which folate status appears to play a key role. However, the precise nature of the link …

Neural tube defects (NTDs), including spina bifida and anencephaly, represent the most
severe and common malformations of the central nervous system affecting 0.7–3 per 1000 …