The concept of treating solid tumors by inhibiting tumor angiogenesis was first articulated
almost 30 years ago. For the next 10 years it attracted little scientific interest. This situation …

Publisher Summary Angiogenesis occurs during embryonic development and during
several physiological and pathological conditions in adult life. Solid tumors induce …

162 SECTION 1/Cancer Biology response to necrotic tumor cells or possibly a host defense
detrimental to the tumor. Another obstacle to research on tumor angiogenesis was the …

Angiogenesis is the process by which new blood vessels are formed from preexisting
microvasculature. To ensure an adequate blood supply, tumor cells release angiogenic …

Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …

Compelling data implicate angiogenesis and tumor-associated neovascularization as a
central pathogenic step in the process of tumor growth, invasion, and metastasis. These …

Malignant tumours are angiogenesis-dependent diseases. Several experimental studies
suggest that primary tumour growth, invasiveness and metastasis require …

Experimental and clinical evidence is here assembled in support of the concept that the
development of a solid tumor progresses from a prevascular phase to a vascular phase. The …

The hypothesis that solid tumors are angiogenesis-dependent has, in the past decade,
generated much new work aimed at understanding the mechanism of angiogenesis itself …

Angiogenesis–the formation of new blood vessels within a tumor (or many other tissue
types)–has become a hotbed of pharmacological research as well as industrial drug …