A growing number of failing clinical trials for cancer therapy are substantiating the need to
upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in …

Tumour microenvironment greatly influences the development and metastasis of cancer
progression. The development of three dimensional (3D) culture models which mimic that …

Glioblastoma (GBM) is an aggressive malignant brain tumor with median survival of 12
months and 5-year survival rate less than 5%. GBM is highly vascularized, and the …

Abstract Two‐dimensional (2D) cancer models have been the standard for drug
development over the past few years, but they frequently do not resemble in vivo properties …

In vitro 3D culture systems provide promising tools for screening novel therapies and
understanding drug resistance mechanisms in cancer because they are adapted for high …

Tumor angiogenesis is critical to tumor growth and metastasis, yet much is unknown about
the role vascular cells play in the tumor microenvironment. In vitro models that mimic in vivo …

Tumor angiogenesis is a hallmark of cancer that has been identified as a critical component
of cancer progression, facilitating rapid tumor growth and metastasis. Anti-angiogenic …

Angiogenesis, the outgrowth of blood vessels, is crucial in development, disease and
regeneration. Studying angiogenesis in vitro remains challenging because the capillary …

Cell–microenvironment interactions play a critical role in the transformation of normal cells
into cancer; however, the underlying mechanisms and effects are far from being well …

Tumor drug delivery is a complex phenomenon affected by several elements in addition to
drug or delivery vehicle's physico-chemical properties. A key factor is tumor …