BACKGROUND: The fornix is the predominant outflow tract of the hippocampus, a brain
region known to be affected early in the course of Alzheimer's disease (AD). The aims of the …

We examined in vivo evidence of axonal degeneration in association with neuronal
pathology in Alzheimer's disease (AD) through analysis of fornix microstructural integrity and …

Importance Magnetic resonance imaging markers of incipient cognitive decline among
healthy elderly individuals have become important for both clarifying the biological …

Purpose To assess for associations between hippocampal atrophy and measures of
cognitive function, hippocampal magnetization transfer ratio (MTR), and diffusion measures …

The fornix is a part of the limbic system and constitutes the major efferent and afferent white
matter tracts from the hippocampi. The underdevelopment of or injuries to the fornix are …

Alzheimer's disease (AD) is the most common form of neurodegenerative dementia.
Researchers have long been focused on the cortical pathology of AD, since the most …

We developed a merged younger-older adult template of the fornix and demonstrated its
utility for studies of aging and preclinical Alzheimer's disease (AD). In Experiment 1 …

The hippocampal complex, strongly implicated in Alzheimer's disease (AD), is a region with
functionally and structurally distinct subfields. Hippocampal subfield volumes may represent …

Decrease in the directionality of water diffusion measured with fractional anisotropy (FA) on
diffusion tensor imaging has been linked to loss of myelin and axons in the white matter …

The fornix and hippocampus are critical to recollection in the healthy human brain. Fornix
degeneration is a feature of aging and Alzheimer9s disease. In the presence of fornix …