Lung cancer is the most common cause of cancer mortality worldwide. Non-small-cell lung
carcinomas (NSCLCs), which represent around 80% of lung tumors, exhibit poor prognosis …

The majority of lung cancers (LC) belong to the non-small cell lung carcinoma (NSCLC)
type. The two main NSCLC sub-types, namely adenocarcinoma (AC) and squamous cell …

Background: Wnt2 is overexpressed and able to promote tumorigenesis in many types of
cancer. However, its expression and role in lung cancer has not been well clarified yet. In …

ABSTRACT Introduction: Wingless-type (Wnt) signaling is tightly regulated at multiple
cellular levels and is dysregulated in lung cancer. Therefore, it offers therapeutic targets for …

BACKGROUND: The Wnt gene family is involved in embryogenesis and tumourigenesis. We
investigated the clinical significance of Wnt1 expression in non-small cell lung cancer …

A recent study indicated that high Wnt5a expression is associated with poor prognosis in
non-small-cell lung cancer (NSCLC) patients; however, the underlying mechanism was not …

Wnt/β-catenin alterations are prominent in human malignancies. In non–small cell lung
cancer (NSCLC), β-catenin and APC mutations are uncommon, but Wnt signaling is …

The Wnt family genes encode multifunctional signaling glycoproteins that are involved in the
regulation of a wide variety of normal and pathological processes including tumorigenesis …

Wnt signaling has recently emerged as a critical pathway in lung carcinogenesis as already
demonstrated in many cancers and particularly in colorectal cancer. We critically discuss in …

Evidence suggests that stem cells may be the source of mutant cells that cause cancers to
develop and proliferate. Wnt signaling has been shown to promote self-renewal in gut …