Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound

L Labrecque, S Lamy, A Chapus, S Mihoubi… - …, 2005 - academic.oup.com
The vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF)
receptors play essential and complementary roles in angiogenesis and combined inhibition …

1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor

SJ Lee, HM Lee, ST Ji, SR Lee, W Mar, YS Gho - Cancer Letters, 2004 - Elsevier
Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular
endothelial growth factor (VEGF) is the most important angiogenic molecule associated with …

Ellagic acid inhibits VEGF/VEGFR2, PI3K/Akt and MAPK signaling cascades in the hamster cheek pouch carcinogenesis model

J Kowshik, H Giri… - Anti-Cancer Agents …, 2014 - ingentaconnect.com
Background: Blocking vascular endothelial growth factor (VEGF) mediated tumor
angiogenesis by phytochemicals has emerged as an attractive strategy for cancer …

[HTML][HTML] Ellagic acid inhibits bladder cancer invasiveness and in vivo tumor growth

C Ceci, L Tentori, MG Atzori, PM Lacal, E Bonanno… - Nutrients, 2016 - mdpi.com
Ellagic acid (EA) is a polyphenolic compound that can be found as a naturally occurring
hydrolysis product of ellagitannins in pomegranates, berries, grapes, green tea and nuts …

The dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-β phosphorylation

S Lamy, V Bédard, D Labbé, H Sartelet… - Cancer prevention …, 2008 - AACR
Platelet-derived growth factor (PDGF)–dependent recruitment of mural cells such as
pericytes and smooth muscle cells plays a central role in the maturation and stabilization of …

Delphinidin, a dietary anthocyanidin, inhibits platelet-derived growth factor ligand/receptor (PDGF/PDGFR) signaling

S Lamy, E Beaulieu, D Labbé, V Bédard… - …, 2008 - academic.oup.com
Most cancers are dependent on the growth of tumor blood vessels and inhibition of tumor
angiogenesis may thus provide an efficient strategy to retard or block tumor growth …

[HTML][HTML] Experimental evidence of the antitumor, antimetastatic and antiangiogenic activity of ellagic acid

C Ceci, PM Lacal, L Tentori, MG De Martino, R Miano… - Nutrients, 2018 - mdpi.com
Ellagic acid (EA) is a naturally occurring polyphenolic compound endowed with strong
antioxidant and anticancer properties that is present in high quantity in a variety of berries …

Emodin inhibits vascular endothelial growth factor‐A‐induced angiogenesis by blocking receptor‐2 (KDR/Flk‐1) phosphorylation

HJ Kwak, MJ Park, CM Park, SI Moon… - … journal of cancer, 2006 - Wiley Online Library
Abstract Emodin (1, 3, 8‐trihydroxy‐6‐methylanthraquinone), an active component in the
root and rhizome of Rheum palmatum, is a tyrosine kinase inhibitor with a number of …

[HTML][HTML] The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors

V Tarallo, L Lepore, M Marcellini, F Dal Piaz… - Journal of Biological …, 2011 - ASBMB
The proangiogenic members of VEGF family and related receptors play a central role in the
modulation of pathological angiogenesis. Recent insights indicate that, due to the strict …

In vitro anti-proliferative activities of ellagic acid

JN Losso, RR Bansode, A Trappey II… - The Journal of nutritional …, 2004 - Elsevier
The potential cytotoxic and anti-proliferative activities of ellagic acid (a naturally occurring
bioactive compound in berries, grapes, and nuts) was evaluated using human umbilical vein …