If specific and functional kinase-or phosphatase-substrate interactions are optimized for
binding compared to promiscuous interactions, then changes in phosphorylation should …

The phosphorylation and dephosphorylation of proteins by kinases and phosphatases
constitute an essential regulatory network in eukaryotic cells. This network supports the flow …

Protein phosphorylation is a dynamic post-translational modification critical for biological
responses. At the level of individual molecules, phosphorylation dynamics can have …

Reversible protein phosphorylation is an essential aspect of mitosis and forms the basis of
nuclear envelope breakdown, chromosome condensation and spindle assembly. Through …

The cellular ability to react to environmental fluctuations depends on signaling networks that
are controlled by the dynamic activities of kinases and phosphatases. Here, to gain insight …

In the past decade, we have gained considerable insight into the identities of various
cytoplasmic signal transduction cascades and the manner in which they operate in response …

Information on extracellular signals and conditions is often transduced by biological systems
using cascades of proteinphosphorylation that affect the activity of enzymes, the localization …

Protein phosphorylation underlies cellular response pathways across eukaryotes and is
governed by the opposing actions of phosphorylating kinases and de-phosphorylating …

The budding yeast Saccharomyces cerevisiae reacts to increased external osmolarity by
modifying many cellular processes. Adaptive signaling relies primarily on the high …

Dynamic changes in protein phosphorylation govern the transitions between different
phases of the cell division cycle. A “tug of war” between highly conserved protein kinases …