The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis

F Damas, CA Libardi, C Ugrinowitsch - European journal of applied …, 2018 - Springer
Resistance training (RT)-induced skeletal muscle hypertrophy is a highly intricate process.
Despite substantial advances, we are far from understanding exactly how muscle …

A review of resistance training-induced changes in skeletal muscle protein synthesis and their contribution to hypertrophy

F Damas, S Phillips, FC Vechin, C Ugrinowitsch - Sports medicine, 2015 - Springer
Muscle protein synthesis (MPS) is stimulated by resistance exercise (RE) and is further
stimulated by protein ingestion. The summation of periods of RE-induced increases in MPS …

Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage

F Damas, SM Phillips, CA Libardi… - The Journal of …, 2016 - Wiley Online Library
Key points Skeletal muscle hypertrophy is one of the main outcomes from resistance training
(RT), but how it is modulated throughout training is still unknown. We show that changes in …

Revisiting the roles of protein synthesis during skeletal muscle hypertrophy induced by exercise

VC Figueiredo - American Journal of Physiology …, 2019 - journals.physiology.org
Protein synthesis is deemed the underpinning mechanism enhancing protein balance
required for skeletal muscle hypertrophy in response to resistance exercise. The current …

[HTML][HTML] An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy

C Lim, EA Nunes, BS Currier, JC Mcleod… - Medicine and science …, 2022 - ncbi.nlm.nih.gov
Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a
highly adaptable tissue that responds to resistance exercise (RE; loading) by …

Muscle Damage in Resistance Training—Is Muscle Damage Necessary for Strength Gain and Muscle Hypertrophy?—

K Nosaka, A Lavender, M Newton… - International Journal of …, 2003 - jstage.jst.go.jp
抄録 The objectives of this review are to delineate muscle damage induced in resistance
training, discuss how muscle damage is associated with increases in strength and/or muscle …

Frequency: the overlooked resistance training variable for inducing muscle hypertrophy?

SJ Dankel, KT Mattocks, MB Jessee, SL Buckner… - Sports Medicine, 2017 - Springer
The principle of progressive overload must be adhered to for individuals to continually
increase muscle size with resistance training. While the majority of trained individuals …

Bigger weights may not beget bigger muscles: evidence from acute muscle protein synthetic responses after resistance exercise

NA Burd, CJ Mitchell… - Applied physiology …, 2012 - cdnsciencepub.com
It is often recommended that heavier training intensities (∼ 70%–80% of maximal strength)
be lifted to maximize muscle growth. However, we have reported that intensities as low as …

Are the hypertrophic adaptations to high and low-load resistance training muscle fiber type specific?

J Grgic, BJ Schoenfeld - Frontiers in physiology, 2018 - frontiersin.org
Skeletal muscle displays considerable biochemical complexity, physiological plasticity, and
cellular heterogeneity (Ohlendieck, 2010). It is well-recognized that resistance training (RT) …

Muscle damage and muscle remodeling: no pain, no gain?

KL Flann, PC LaStayo, DA McClain… - Journal of …, 2011 - journals.biologists.com
Skeletal muscle is a dynamic tissue that responds adaptively to both the nature and intensity
of muscle use. This phenotypic plasticity ensures that muscle structure is linked to patterns of …