Pancreatic acini and islets are believed to differentiate from common ductal precursors
through a process requiring various growth factors. Epidermal growth factor receptor (EGF …

Epidermal growth factor receptor (EGF-R) signaling is essential for proper fetal development
and growth of pancreatic islets, and there is also evidence for its involvement in β-cell signal …

Pancreatic islet development is impaired in mice lacking EGFRs (epidermal growth factor
receptors). Even partial tissue-specific attenuation of EGFR signalling in the islets leads to …

During embryonic life, the development of a proper mass of mature pancreatic tissue is
thought to require the proliferation of precursor cells, followed by their differentiation into …

Pancreatic organogenesis has been a classic example of epitheliomesenchymal
interactions. The nature of this interaction, and the way in which endocrine, acinar and …

A comparative analysis of mouse and human pancreatic development may reveal common
mechanisms that control key steps as organ morphogenesis and cell proliferation and …

The aim of this study was to investigate the phenotypic plasticity of pancreatic islets of
Langerhans. Quiescent adult human islets were induced to undergo a phenotypic switch to …

Although several studies have suggested that insulin-secreting cells can be generated in
vitro from cells residing in adult exocrine pancreas, neither the origin of these cells nor their …

A key question in diabetes research is whether new β-cells can be derived from
endogenous, nonendocrine cells. The potential for pancreatic ductal cells to convert into β …

Pancreatic development is a classic example of epithelium–mesenchyme interaction. During
embryonic life, signals from the mesenchyme control the proliferation of precursor cells …