Dendritic cells in allergic airway inflammation

AS Bharadwaj, AK Bewtra… - Canadian Journal of …, 2007 - cdnsciencepub.com
Dendritic cells (DCs) are primary antigen-presenting cells involved in interactions with T
cells leading to the proliferation of TH1 or TH2 cell types. In asthma, predominance of TH2 …

The role of dendritic cells in immune regulation and allergic airway inflammation

JW Upham - Respirology, 2003 - Wiley Online Library
Dendritic cells (DC) are potent antigen presenting cells that display an extraordinary
capacity to present antigen to naïve T‐cells and initiate primary immune responses. In the …

Why are dendritic cells important in allergic diseases of the respiratory tract?

JW Upham, PA Stumbles - Pharmacology & therapeutics, 2003 - Elsevier
Increasing evidence points to the role of antigen-presenting dendritic cells (DC) in regulating
adaptive immune responses. DC are especially sensitive to signals derived from microbes …

Human dendritic cells in allergic asthma and rhinitis

A Froidure, C Pilette - Medecine Sciences: M/S, 2015 - europepmc.org
The role of dendritic cells (DC) in the pathogenesis of allergic asthma and rhinitis has been
highlighted for 15 years. In this review, we summarize key findings concerning DC function …

Lung dendritic cells and the inflammatory response

MH Grayson - Annals of Allergy, Asthma & Immunology, 2006 - Elsevier
OBJECTIVE: To discuss the role of conventional and plasmacytoid dendritic cells in inducing
and modulating immune responses in the lung. DATA SOURCES: The primary literature and …

Dendritic cell subsets and immune regulation in the lung

HJ de Heer, H Hammad, M Kool, BN Lambrecht - Seminars in immunology, 2005 - Elsevier
The lung is continuously exposed to inhaled particles, microbes and harmless antigens to
which either immunity or tolerance is induced. Dendritic cells are mainly recognized for their …

[HTML][HTML] Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation

BN Lambrecht, M De Veerman… - The Journal of …, 2000 - Am Soc Clin Investig
The aim of this study was to investigate whether dendritic cells (DCs) can induce
sensitization to aeroallergen in a mouse model of allergic asthma. Ovalbumin-pulsed (OVA …

Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation

H Hammad, BN Lambrecht - Journal of allergy and clinical immunology, 2006 - Elsevier
Dendritic cells (DCs) are crucial in determining the outcome of antigen encounter and
integrating signals derived from the antigen, its inflammatory context, and the host …

Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma

H Hammad, BN Lambrecht - Nature Reviews Immunology, 2008 - nature.com
Dendritic cells (DCs) are generally held responsible for initiating and maintaining allergic T
helper 2 (TH2)-cell responses to inhaled allergens in asthma. Although the epithelium was …

Aeroallergen challenge promotes dendritic cell proliferation in the airways

TZ Veres, S Voedisch, E Spies, J Valtonen… - The Journal of …, 2013 - journals.aai.org
Aeroallergen provocation induces the rapid accumulation of CD11c+ MHC class II (MHC II)+
dendritic cells (DCs) in the lungs, which is driven by an increased recruitment of blood …