Cell cycle progression is controlled by signaling pathways that direct the biochemical
changes cells undergo in preparation for DNA replication and subsequent cell division …

LSF (late SV40 factor) is a mammalian transcription factor that regulates expression of both
viral genomes and cellular genes, including that encoding thymidylate synthase, a critical …

Signal transduction cascades induced by mitogenic stimuli directly drive the modification of
preexisting pools of cellular proteins, including transcription factors. Interestingly, multiple …

Transcriptional regulation in mammalian cells is driven by a complex interplay of multiple
transcription factors that respond to signals from either external or internal stimuli. A single …

Transcription factor LSF is required for progression from quiescence through the cell cycle,
regulating thymidylate synthase (Tyms) expression at the G1/S boundary. Given the constant …

Understanding the mechanism by which transcription initiation occurs requires knowledge of
the proteins that bind specific DNA sequences to regulate gene expression. The simian virus …

Late SV40 factor (LSF) is a CP2 family transcription factor involved in cell cycle regulation. In
liver cancer, LSF is an oncogene, in part due to its role in upregulation of osteopontin …

The thymidylate synthase (TS) gene, which is induced at the G 1–S transition in growth‐
stimulated cells, encodes an enzyme that is essential for DNA replication and cell survival …

The HeLa transcription factor LSF has been purified by heparin-agarose and DNA affinity
chromatography, and its DNA binding and transcription properties have been characterized …

Cyclin-dependent protein kinases (Cdks) play a key role in the cell division cycle of
eukaryotic cells. Cdc2, the first mammalian Cdk that was discovered, is expressed in S …